The present invention provides a polypeptide having a complex amino acid sequence derived from a consensus sequence representing capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the present invention provides virus-like particles comprising at least one complex polypeptide. These virus-like particles have antigenic epitopes of two or more circulating strains of the non-enveloping virus and increase antiserum cross-reactivity to one or more circulating strains of the non-enveloping virus. Methods of making a vaccine preparation comprising complex virus-like particles and complex virus-like particles are disclosed.
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