PROCESS FOR THE MANUFACTURE OF ISAVUCONAZOLE OR RAVUCONAZOLE

摘要

Particular stereoisomer and enantiomer enrichment triazoles comprising the Reformatsky reaction between ketones and 2-halozinc propionate esters, followed by a splitting step, preferably an enzyme splitting step using an esterase enzyme. It relates to a method for preparing the compounds isabuconazole and rabuconazole.