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SCF -1 BISPECIFIC ANTIBODY TARGETING SCF AND GALECTIN-1 AND USE THEREOF

机译:SCF -1双特异性抗体靶向SCF和Galectin-1及其用途

摘要

The present invention relates to a composition for preventing or treating an angiogenesis-related disease and a dual target antibody targeting SCF (Stem Cell Factor) and Galectin-1. The present invention prevents or treats angiogenesis-related diseases comprising the antibody and a dual target antibody derived from a human monoclonal antibody capable of effectively inhibiting angiogenesis by simultaneously neutralizing SCF and galectin-1 involved in angiogenesis. It provides a pharmaceutical composition. The dual target antibody according to the present invention can effectively prevent or treat angiogenesis-related diseases that cause bleeding by neutralizing two targets involved in angiogenesis at the same time, thereby increasing the permeability of blood vessels through abnormal angiogenesis.
机译:本发明涉及用于预防或治疗与血管生成有关的疾病的组合物以及靶向SCF(干细胞因子)和半乳凝素-1的双重靶标抗体。本发明预防或治疗血管生成相关疾病,所述疾病包含抗体和源自人单克隆抗体的双重靶标抗体,所述人单克隆抗体能够通过同时中和参与血管生成的SCF和galectin-1来有效抑制血管生成。它提供了一种药物组合物。根据本发明的双靶抗体可以通过同时中和参与血管生成的两个靶,从而通过异常的血管生成来增加血管的通透性,从而有效地预防或治疗引起出血的血管生成相关疾病。

著录项

  • 公开/公告号KR102131898B1

    专利类型

  • 公开/公告日2020-07-08

    原文格式PDF

  • 申请/专利权人 주식회사 노벨티노빌리티;

    申请/专利号KR20180127615

  • 发明设计人 박상규;

    申请日2018-10-24

  • 分类号C07K16/24;G01N33/68;

  • 国家 KR

  • 入库时间 2022-08-21 11:04:13

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