3 1--4- A method for producing 1-ethyl-4-phenylpiperazine derivative by three-component reaction using aromatic compounds amines and nucleophiles

摘要

In the present specification, a first reaction step in which an aromatic compound in which a trifluoromethanesulfonate group and a trimethylsilyl group are bonded to each other in an ortho position is formed as an amine intermediate; A second reaction step in which the arin intermediate is formed of a quaternary ammonium salt by reacting with dabco; And a third reaction step of reacting the quaternary ammonium salt with a nucleophile, wherein the first to third reaction steps are performed in a one-pot reaction. Disclosed is a method for producing a phenylpiperazine derivative.