THERAPEUTIC REGIMENS AND METHODS FOR IMPROVING VISUAL FUNCTION IN VISUAL DISORDERS ASSOCIATED WITH AN ENDOGENOUS RETINOID DEFICIENCY

摘要

Provided herein is endogenous production, comprising administering a synthetic retinal derivative over a period of 2-7 days as divided doses, followed by a 7-28 day rest period, and then administering a second dose of the synthetic retinal derivative. A treatment regimen for improving visual function in subjects with deficiency of 11-cis retinal is provided. Preferred synthetic retinal derivatives are 9- or 11-cis-retinyl esters. Diseases associated with the deficiency of endogenous 11-cis retinal produced include retinitis pigmentosa and lever adenocarcinoma.