- A biodegradable scaffold composition having semi-IPN structure for tissue regeneration and a preparation method thereof

摘要

The present invention relates generally to silk fibroin-based materials for biomedical applications, for example in soft tissue repair, enlargement and/or reconstruction. It also relates to his application method. The composition described in the present invention can be injected directly. It can also be applied to existing biodegradable supports. It is also injectable, allowing them to be placed in tissue to be treated with a minimally invasive procedure (eg, injection). In some embodiments, the main composition described in the present invention, fibroin, is a natural polymer, blending collagen, hyaluronic acid and silk fibroin, gelatin, alginate, chitosan, etc., known as ECM materials, to form an interpenetrating polymer network structure on silk fibroin, , It is possible to prevent the complex from expanding when inserted into the tissue to maintain its original expanded volume in the tissue. It can be used, for example, as a filler to replace tissue voids for tissue repair and/or enlargement, or as a scaffold to aid tissue regeneration and/or reconstruction. In addition, the present invention includes increasing the cell adhesion and tissue compatibility by applying a silk fibroin complex having a cross-penetrating polymer network structure to a polyester-based synthetic polymer. In addition, the present invention also includes a method of granulating a silk fibroin complex having a cross-penetrating polymer network structure and using it as a support for tissue regeneration. In addition, the present invention also includes a method of coating a silk fibroin complex having a cross-penetrating polymer network structure with hydroapatite as a support for bone regeneration.