DPP4 Composition for preventing or treating myocardial fibrosis comprising DPP4 inhibitor as an active ingredient

摘要

The present invention relates to a composition for preventing or treating myocardial fibrosis comprising a DPP4 inhibitor (dipeptidyl peptidase 4 inhibitor, DPP4i) as an active ingredient, wherein the DPP4 inhibitor inhibits DPP4 activity in the blood and heart, and of TGF-β1 It suppresses the expression and phosphorylation of Smad2/3 and suppresses the expression of collagen type I and type III, thereby suppressing myocardial fibrosis induced by high fat diet or obesity, and can be usefully used for the prevention or treatment of myocardial fibrosis.