首页> 外国专利> Novel Bifidobacterium longum strain or Lactobacillus rhamnosus strain for preventing or treating obesity and the use thereof

Novel Bifidobacterium longum strain or Lactobacillus rhamnosus strain for preventing or treating obesity and the use thereof

机译:用于预防或治疗肥胖的新型长双歧杆菌菌株或鼠李糖乳杆菌菌株及其用途

摘要

The present invention relates to a novel Bifidobacterium longum strain or Lactobacillus rhamnosus strain having a prophylactic or therapeutic effect of obesity, and to a use thereof, the lactic acid bacterium Bifidobacterium longum of the present invention, and Lactobacillus rhamnosus ( Lactobacillus rhamnosus ) The treatment of each strain caused brown localization of white adipocytes, and in particular, it was confirmed that the expression of genes specific to beige adipocytes and brown adipocytes was significantly increased compared to the untreated control. In addition, as a result of the experiments of obese mice fed on a high fat diet, each strain showed a remarkable effect of suppressing weight gain compared to the negative control group, and the effect of increasing the expression of fever-specific genes in white adipose cells of the mice was confirmed. Therefore, each of the Lactobacillus Bifidobacterium longum strain and Lactobacillus rhamnosus strain exhibits an anti-obesity effect, so it can be usefully used as a food, medicine or feed for the prevention or treatment of obesity, which is very useful in related industries.
机译:本发明涉及具有肥胖预防或治疗作用的新型长双歧杆菌菌株或鼠李糖乳杆菌菌株,及其用途,本发明的乳酸菌长双歧杆菌和鼠李糖乳杆菌。 (鼠李糖乳杆菌)每种菌株的处理均引起白色脂肪细胞的棕色定位,特别是,与未处理的对照相比,已证实米色脂肪细胞和棕色脂肪细胞特异的基因表达明显增加。另外,通过高脂饮食喂养的肥胖小鼠的实验结果,与阴性对照组相比,每种菌株均显示出显着的抑制体重增加的效果,以及增加白热病特异性基因表达的效果。确认小鼠的脂肪细胞。因此,长双歧杆菌菌株和鼠李糖乳杆菌菌株均显示出抗肥胖作用,因此可以有效地用作预防或治疗肥胖的食品,药物或饲料,这在相关行业中非常有用。

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