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OBTAINING LATANOPROSTENE BUNOD OF REQUIRED QUALITY PRESET BY CHROMATOGRAPHY WITH GRAVITATIONAL ELUTION
OBTAINING LATANOPROSTENE BUNOD OF REQUIRED QUALITY PRESET BY CHROMATOGRAPHY WITH GRAVITATIONAL ELUTION
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机译:用重力洗脱色谱法获得所需质量的拉坦前列腺素
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摘要
The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silica gel column chromatography where the used silica gel is irregular silica gel or spherical silica gel an as eluent and eluent mixture consisting of an apolar and a polar solvent is used and if desired, contamination of the purified compound of formula I arising from the solvents are removed by silica gel filtration chromatography.
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