首页>
外国专利>
METHODS OF OVERCOMING IMMUNOLOGICAL TOLERANCE USING MULTIPLE GUIDING RNA
METHODS OF OVERCOMING IMMUNOLOGICAL TOLERANCE USING MULTIPLE GUIDING RNA
展开▼
机译:利用多种指导性RNA克服免疫耐受性的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Methods and compositions are provided for making non-human animals with reduced tolerance of a foreign antigen of interest and making antigen-binding proteins against that foreign antigen of interest using such animals. The methods and compositions employ CRISPR/Cas9 systems using multiple guide RNAs to reduce or eliminate expression of a self-antigen homologous to or sharing an epitope of interest with the foreign antigen of interest or to reduce or eliminate expression of an epitope on the self-antigen that is shared with the foreign antigen of interest.
展开▼