where e = 2.7182818 - mathematical constant - base of natural logarithm, α0 = 2.386696717005736 - coefficient, α1 = -0.00276285111326 - coefficient, α2 = 0.00189985337763 - coefficient, α3 = -0.28206543500757 - coefficient, x1 - number of receptors TNFR2 on CD3+ T-lymphocytes, x2 - amount of TNFR1 on T-helper cells CD4+CD45R0+, x3 - percentage TNFR1 positive cells among naive T-helper cells CD4+CD45RA+. If value P ≥ 0.5 there is a probability of rheumatoid arthritis.;EFFECT: use of this method for mononuclear subpopulations estimation: TNFR1+TNFR2 cells, cells among naive T-helper cells and number of type 1 receptors on T-helper memory cells, as well as type 2 receptors on CD3+ T-cells enables distinguishing indicators of healthy donors and rheumatoid arthritis patients at an early stage.;3 cl, 2 tbl, 5 ex, 1 dwg"/>
公开/公告号RU0002735738C1
专利类型
公开/公告日2020-11-06
原文格式PDF
申请/专利权人
申请/专利号RU2019144401
发明设计人 SENNIKOV SERGEJ VITALEVICH (RU);ALSHEVSKAYA ALINA ANATOLEVNA (RU);LOPATNIKOVA YULIYA ANATOLEVNA (RU);ZHUKOVA YULIYA VLADIMIROVNA (RU);KIREEV FEDOR DMITRIEVICH (RU);SIZIKOV ALEKSEJ EDUARDOVICH (RU);SHKARUBA NADEZHDA SERGEEVNA (RU);CHUMASOVA OKSANA ALEKSANDROVNA (RU);
申请日2019-12-24
分类号G01N33/577;
国家 RU
入库时间 2022-08-21 11:02:47