METHOD FOR PREDICTION OF LETHAL OUTCOME IN CLINICAL COURSE OF COINFECTION OF HIV AND TUBERCULOSIS, ACCOMPANIED BY MULTIPLE DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to infectious diseases, phthisiology and therapy. Disclosed is a method for prediction of lethal outcome in clinical course of HIV-tuberculosis coinfection, wherein in the patients with the detected multiple drug-resistant Mycobacterium tuberculosis and the known amount of CD4-lymphocytes, venous blood samples are taken, blood plasma isolation and ELISA test to determine concentration of nonspecific total immunoglobulins IgE in IU/ml, IgM in mg/ml, IgA in mg/ml and secretory IgA in mg/l in blood plasma, calculating prediction coefficient of lethal outcome (CP) equal to ratio of product of their concentrations to CD4-lymphocyte count in 1 mcl of blood and if this coefficient exceeds value 200, lethal outcome is predicted with 56.7-fold relative risk.;EFFECT: invention enables predicting the unfavorable outcome of the disease with a high probability and correcting the therapeutic approach of the given cohort of patients, which contributes to reducing mortality.;1 cl, 3 tbl, 3 ex