METHODS OF TREATING CANCER USING PD-1 AND PD-L1 ANTAGONISTS IN COMBINATION WITH RADIATION THERAPY

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, and concerns a method of treating cancer in a patient, comprising administering to said patient at least one fractional radiation therapy fraction; administering to said patient at least one PD-1 and/or PD-L1 antibody, wherein at least one PD-1 and/or PD-L1 antibody is administered on the same day as the radiation therapy fraction, or for a period of not more than 4 days, inclusive, where said fraction is 2.2 Gy or less and where the cancer is bladder cancer, breast cancer, colorectal cancer, head and neck cancer, liver cancer, lung cancer, ovarian cancer, pancreatic cancer or kidney cancer.;EFFECT: invention provides higher cancer survival.;17 cl, 11 dwg, 1 tbl, 1 ex