COMPOSITION FOR INJECTION BASED ON A FAT EMULSION OF CABAZITAXEL, A METHOD FOR ITS PREPARATION AND APPLICATION

摘要

FIELD: medicine; pharmaceuticals.;SUBSTANCE: present invention provides a composition for injection based on a fat emulsion of cabazitaxel, wherein the composition for injection based on a fat emulsion of cabazitaxel contains cabazitaxel, medium-chain triglyceride for injection and lecithin. Present invention also discloses a method of producing an injectable composition based on a fat emulsion of cabazitaxel and use thereof in preparing a medicament for treating prostate cancer. What is described is a formulation for cabazitaxel fat emulsion for treating prostate cancer, consisting of the following components, wt/vol % (wt/vol): cabazitaxel 0.05–0.5 %; medium-chain triglyceride for injection 2–10 %; lecithin 1–8 %; auxiliary emulsifier 0–0.5 %; isotonicity regulator 0–2.2 %; stabilizer 0.01–0.03 %; pH regulator—adjust pH to 3.0–7.0; lyophilized proppant 0–30 %; water for injection—up to 100 %, wherein the stabilizer is oleic acid and/or sodium oleate.;EFFECT: technical result is the development of a stable composition based on a fat emulsion of cabazitaxel with high content of the drug.;19 cl, 4 tbl, 20 ex