POLYANTIGENIC VACCINE FOR PREVENTING AND ADJUNCTIVE TREATMENT OF TUBERCULOSIS

摘要

FIELD: medicine; pharmaceuticals.;SUBSTANCE: invention relates to medicine and pharmaceutics and represents a recombinant tuberculosis vaccine comprising an effective amount of recombinant protein ESAT6-CFP10-Ag85a-Rv2660c, which is fused mycobacterial proteins ESAT-6, CFP10, Ag85a, Rv2660c with histidine tag with length of 8 residues, and an adjuvant represented by a CPG oligonucleotide and a muramyl dipeptide, wherein the recombinant protein and the adjuvant are immobilized on carrier particles from a lactic and glycolic acid copolymer PLGA.;EFFECT: increased immunogenic action of recombinant protein-antigen ESAT6-CFP10-Ag85a-Rv2660c in combination with adjuvant presented by CpG-ODN of class A and N-acetylmuramyl-L-alanyl-D-isoglutamine.;5 cl, 13 dwg, 10 tbl, 7 ex