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SOLUBLE UNIVERSAL REINFORCING ADCC SYNTHETIC FUSED GENE, PEPTIDE TECHNOLOGY AND USE THEREOF
SOLUBLE UNIVERSAL REINFORCING ADCC SYNTHETIC FUSED GENE, PEPTIDE TECHNOLOGY AND USE THEREOF
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机译：可溶性通用增强ADCC合成融合基因，肽技术及其用途
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摘要
FIELD: biotechnology.;SUBSTANCE: invention relates to peptide enhancers of antibody-dependent cell-line cytotoxicity (ADCC), and can be used in medicine to amplify ADCC in a combination with a therapeutic anti-cell surface antigen, indicative of a malignant growth. A fused protein consisting of a high-affinity Fc-binding domain, a high-affinity CD3-binding domain and a flexible serine-glycine linker is obtained.;EFFECT: present invention provides higher therapeutic effectiveness of antibodies by using technology of soluble universal protein-enhancer ADCC (SUAEP), id est ready-to-use adapter-like, soluble universal ADCC amplifying protein.;6 cl, 23 dwg, 4 ex
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机译：技术领域：本发明涉及抗体依赖性细胞系细胞毒性（ADCC）的肽增强剂，并且可以在医学中与治疗性抗细胞表面抗原联合使用以扩增ADCC，表明恶性生长。获得了由高亲和力Fc结合结构域，高亲和力CD3结合结构域和柔性丝氨酸-甘氨酸接头组成的融合蛋白。效果：本发明通过利用可溶性通用蛋白技术提供了更高的抗体治疗效果。 -增强ADCC（SUAEP），最易于使用的类似适配器的可溶性通用ADCC扩增蛋白。; 6 cl，23 dwg，4 ex
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