THERAPEUTIC AGENTS AIMED AT SHORTENED PROTEINS OF ADENOMATOUS POLYPOSIS COLI (APC)

摘要

FIELD: medicine; pharmaceuticals.;SUBSTANCE: invention relates to a compound of formula I-b:; ;(Formula I-b),;where L is SO₂, each R¹ and R² is independently selected from a group consisting of H and C_1-4 alkyl; R³ is selected from a group consisting of C_1-3 alkyl, optionally substituted with R²¹; ring is selected from a group consisting of; , , , , , , , , , , and $; each R⁴, R⁵, R⁷ and R⁸ is independently selected from a group consisting of H, F, Cl, Br, C_1-4 alkyl, N₃, NH₂, CF₃, OCHF₂, OCF₃, OC_1-4 alkyl, benzoyl, -OCH₂C≡CH, CN, and NO₂; R⁶ is selected from a group consisting of H, Br and R¹⁷; R⁹ is H; R¹⁰ is H or Br; each R¹¹, R¹² and R¹³ independently represents H, F, Cl or Br; each R¹⁴, R¹⁵ and R¹⁶ independently represents H, methyl or ethyl; R¹⁷ is phenyl, optionally substituted with one or more substitutes selected from the group consisting of NO₂ and -NR¹⁸CO-(C_1-4alkyl); each R¹⁸ independently represents H; each R²¹ is independently selected from a group, consisting of H, CN and OR²²; each R²² independently represents H; and to compounds of similar structure, presented by specific chemical formulas, as well as to a pharmaceutical composition for treating colon cancer, comprising a therapeutically effective amount of such compounds, and a method of treating colon cancer.;EFFECT: therapeutic agents aimed at truncated proteins of adenomatous polyposis coli (APC) are proposed.;9 cl, 62 dwg, 1 tbl, 3 ex