AGENT FOR INHIBITION OF REPLICATION OF SARS-COV-2 VIRUS MEDIATED BY RNA INTERFERENCE

摘要

FIELD: biotechnology.;SUBSTANCE: invention refers to biotechnology, virology, molecular biology and immunology. Described is an agent for specific inhibition of replication of SARS-CoV-2 coronavirus mediated by RNA interference using small interfering RNA (siRNA). Agent for genome SARS-CoV-2 virus replication inhibition, mediated by RNA interference, contains an effective number of molecules of small interfering nucleic acids (siRNA) in the form of complementary duplexes represented with nucleotide sequences selected from a group consisting of SEQ ID NO 4 – SEQ ID NO 33. Recognition of siRNA complexes with virus RNA and its mRNA transcripts results in activation of RNA interference mechanism and attraction of cell enzymes providing degradation of genome RNA of SARS-CoV-2 virus.;EFFECT: invention extends the range of means of inhibiting replication of SARS-CoV-2 coronavirus.;7 cl, 1 tbl, 6 ex, 13 dwg