NANOPARTICLES BASED ON BIODEGRADABLE POLYMERS WITH ANTICANCER DRUGS ENCAPSULATED THEREIN

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to oncology, to nanoparticles based on biodegradable polymers with anticancer preparations encapsulated therein and can be used for treating malignant growths. Nanoparticles based on biodegradable polymers with anticancer preparations encapsulated therein are made in the form of spherical double-layer structures containing an outer insulating layer and inner spherical part made of biodegradable polymers selected from polyglycolide group, poly-DL-lactide, polylactide-glycolides (PLGA) containing 50 % of L-isomer and 50 % of D-isomer or polylactide-glycolides (PLGA), containing 85–90 % of L-isomer and 10–15 % of D-isomer, inner spherical part of two-layer structure is encapsulated in its volume with nanoparticles of anti-tumour preparations in amount of 36 to 54 wt. %. Antineoplastic preparations are selected from a group of fluorouracil, or a mixture of fluorouracil with exogenous siRNA205, or a mixture of fluorouracil with exogenous siRNA205 and cisplatin, or a mixture of fluorouracil with cisplatin. Nanoparticles of anti-tumour preparations can be adsorbed on the surface of the inner spherical part of the two-layer structure. Spherical nanoparticles are made with diameters of 10 to 200 nm, and thickness of outer insulating layer is selected depending on expected time of controlled delivery of anti-tumour preparations to affected tissue and makes 0.15–0.32 of external diameters of nanoparticles. Produced nanoparticles provide effective inhibition of growth of malignant growth, increased cytostatic activity and selective effect on tumour cells. Besides, obtained nanoparticles provide targeted effect of anti-cancer preparations on tumour cells without isolation of anticancer preparations in surrounding tissues during movement to tumour cells with simultaneous reduction of treatment time and reduced biochemical load on patient's body.;EFFECT: invention provides high clinical effectiveness with obtaining a stable therapeutic effect ensured by the inhibitory effect on malignant growth.;4 cl, 1 tbl, 3 dwg