Composition for inducing selective apoptosis undifferentiated pluripotent stem cells comprising prunellae spica extracts and the Method for inducing selective apoptosis using the same

摘要

The present invention relates to a composition for inducing selective apoptosis of undifferentiated pluripotent stem cells containing an extract of Hagocho as an active ingredient, specifically, inducing selective apoptosis of undifferentiated pluripotent stem cells comprising an extract of Hagocho as an active ingredient. Preparation of a composition, a composition for selective removal of undifferentiated pluripotent stem cells containing the Hagocho extract as an active ingredient, (a) preparing a cell sample comprising undifferentiated pluripotent stem cells and differentiated cells; And (b) selectively removing the undifferentiated pluripotent stem cells by treating the cell sample with the Hagocho extract; and the method for removing the undifferentiated pluripotent stem cells, and removing the undifferentiated pluripotent stem cells by the above method. Cell composition. In a situation in which undifferentiated stem cells that remain in the process of differentiating pluripotent stem cells have the problem of forming teratomas (teratomas) upon transplantation with a cell therapy agent, the composition comprising the extract of Hagocho of the present invention is a pluripotent stem cell. Since it is possible to effectively remove only the stem cells remaining undifferentiated in the process of differentiation, it can be used to develop a safe stem cell therapeutic agent.