15. Beta. - [3-propanamide] - substituted estra-1,3,5 (10) - trien-17-one compounds and their 17 oxime for use in the inhibition of 17. Beta. - hydroxylated dehydrogenase

摘要

Problem 15 - [3 - propanamide] - substituted estra-1,3,5 (10) - trien-17-one compounds and their 17 oxime for use in the inhibition of 17. Beta. - hydroxysteroid dehydrogenase.SolutionThe present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts.1In the equation, R1-R4 are defined in the claims.The present invention further treats the use of inhibitors as inhibitors of 17. Beta. - HSD1 and inhibition of the 17. Beta. - HSD1 enzyme and \/ or steroid hormone dependent disorders or disorders such as steroid hormone dependent disorders or disorders requiring a reduction in endogenous estradiol concentration It relates to use in prevention.The present invention also relates to compounds of formula (II) which define 17 - ketone compounds corresponding to 17 - oxime of formula (I).The present invention further relates to a pharmaceutical composition comprising one or more of the above compounds and a pharmaceutically acceptable salt thereof as preparation of said compound and as an active ingredient.No selection