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Combination dosage form of mu opioid receptor antagonist and opioid drug
Combination dosage form of mu opioid receptor antagonist and opioid drug
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摘要
The present invention relates to a solid composition of peripheral mu opioid antagonist aceloplan, an immediate release form of mu opioid antagonist aceloplan sulfate, and an opioid that may be in extended release, sustained release, controlled release, or controlled release form Provided are analgesic combination dosage forms and methods of preparing such combination dosage forms. The present invention provides, for example, (a) between about 50% and about 95% by weight of aceloplan sulfate, (b) between about 5% and about 50% by weight of polyvinyl alcohol, (c) about 0% From about 45% polyethylene glycol 3350, and (d) from about 0% to about 10% ascorbic acid.
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