Method for producing radiofluorine-labeled 2-(3-pyridinyl)-1H-benzimidazole derivative and method for producing radiopharmaceutical

摘要

PROBLEM TO BE SOLVED: To provide a technique for simply purifying a specific radioactive fluorine-labeled 2-(3-pyridinyl)-1H-benzimidazole derivative compound by a method not relying on an HPLC method. SOLUTION: A precursor compound and a radioactive fluorine-labeled by carrying out a radiofluorination reaction on a precursor compound of a specific radioactive fluorine-labeled 2-(3-pyridinyl)-1H-benzimidazole derivative compound or a salt thereof. A radiofluorination step of obtaining a first reaction mixture containing a compound, a first reaction mixture and a polyvalent acid or a salt thereof are mixed to give a polyvalent anion to the precursor compound to give a polyvalent anion. Radioactivity including an anionization step of obtaining a second reaction mixture containing an anion compound and a radiofluorine-labeled compound, and a purification step of purifying the radiofluorine-labeled compound from the second reaction mixture by a solid phase extraction method. Provided is a method for producing a fluorine-labeled compound. [Selection diagram] None