Estimation of Radiation Dose to Indian Reference Man due toIndigenously Produced Renal and Liver RadiopharmaceuticalsDosimetry of Indigenously Produced Radiopharmaceuticals

摘要

Board of Radiation and Isotope Technology (BRIT), Department of Atomic Energy,India has been commercially supplying cold kits for 99mTc based radiopharmaceuticals sincethe last few decades after necessary Quality Control, including tests for sterility andbiodistribution pattern. These kits are being regularly used by various Nuclear Medicinecentres in India. Although the data on the doses received by the critical organs, on use ofdifferent radiopharmaceuticals are available in literature, it would be ideal to provide actualdata for BRIT kits to the users. With the aim to carry out dosimetric studies for the variousradiopharmaceuticals prepared using BRIT supplied kits, we started with the agents used forrenal and liver scintigraphy. These doses were estimated based on the animal studies.Assuming that the radiopharmaceuticals undergo similar metabolism in humans as thelaboratory animals, the percentage uptake obtained in the animal were applied to the IndianReference Man and the doses were calculated theoretically. The cumulative radiation dosesreceived by kidneys, liver, intestine, lungs, bladder and stomach have been calculated andcompared with the doses published by ICRP. The cumulative radiation doses to liver due toSulphur Colloid, Mebrofenin and Phytate were 10.3E-02, 0.3E-02 and 9.6E-02 mGy/MBqrespectively and to kidneys due to DTPA, EC and GHA were 3.07E-03, 6.4E-03 and 6.4E-02mGy/MBq respectively. In case of Indian Reference Man, the dose estimates due to EC andMebrofenin radiopharmaceuticals are compared with MAG3 and IDA of ICRP reference manrespectively. It is well known that both height and weight for the Reference Indian are lowerthan ICRP values (25% for weight and 4% for height). The doses calculated for IndianReference Man were higher or nearly the same, as the values reported by ICRP, in mostcases.