Upconversion Nanoparticles of Inhibiting Aggregation of β-Amyloid

摘要

The present invention relates to up-conversion nanoparticles for inhibiting beta-amyloid aggregation, and more specifically, a porous shell containing a photosensitizer characterized in that oxidizing beta-amyloid is generated by generating reactive oxygen species by near infrared irradiation. It is about upconversion nanoparticles. Therefore, the use of the upconversion nanoparticles on which the porous shell containing the photosensitizer of the present invention is deposited can effectively inhibit the aggregation of beta-amyloid and reduce the toxicity of beta-amyloid, and thus the aggregation of beta-amyloid It can be effectively used for the wide dynamic treatment of various degenerative neurological diseases such as Alzheimer's disease, Parkinson's disease, stroke, and Huntington's disease caused by.