VIRUS VACCINAL POUR THÉRAPIE PAR PRODROGUE ACTIVÉE PAR DES ENZYMES EXPRIMÉES PAR DES GÈNES

摘要

Methods of making vaccinia viruses for gene-directed prodrug therapy are disclosed and their use in the treatment of disease is provided. In particular, the anti-tumor effects of vaccinia viruses that are modified to express a prodrug-activating enzyme are disclosed.