NOUVEAUX DOSAGES DE CRIBLAGE POUR IDENTIFIER DES COMPOSÉS CAPABLE DE REVERSER LA LATENCE DU HIV-1

摘要

The present invention relates to a method for identifying compounds which reverse HIV-1 latency in a subject and can therefore be therapeutically used for eliminating a latent viral reservoir in a subject infected with HIV-1. Further, the present invention relates to a method for identifying compounds which stabilize HIV-1 latency in a subject and can therefore be therapeutically used for preventing replication and outgrowth of latent HIV-1. In yet another aspect, the present invention relates to a compound that increases or decreases the expression level of the HIV-1 Vpu gene for use in method of treating an HIV-1 infection in a subject in need thereof. In yet another aspect, the present invention relates to a compound that increases or decreases the binding between the HIV-1 Vpu protein and NF-κB for use in method of treating an HIV-1 infection in a subject in need thereof.