COMPOSITIONS D'ÉVALUATION ET DE MODULATION DES RÉPONSES IMMUNITAIRES À L'AIDE DE SIGNATURES GÉNÉTIQUES DE CELLULES IMMUNITAIRES

摘要

The present invention provides markers, marker signatures and molecular targets that correlate with dysfunction of immune cells and are advantageously independent of the immune cell activation status. The present markers, marker signatures and molecular targets provide for new ways to evaluate and modulate immune responses. Therapeutic methods are also provided to treat a patient in need thereof who would benefit from an increased immune response.