COMPOSITION PHARMACEUTIQUE COMPRENANT UN COMPRIMÉ SPHÉROÏDAL À UNITÉS MULTIPLES CONTENANT DE L'ÉSOMÉPRAZOLE ET UN SEL DE QUALITÉ PHARMACEUTIQUE DE CELUI-CI, ET PROCÉDÉ DE PRÉPARATION DE LA COMPOSITION PHARMACEUTIQUE

摘要

Provided are a pharmaceutical composition including a core in a form of a multi-unit spheroidal tablet (MUST) containing esomeprazole or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical composition is dissolved by 50 percent (%) or more within 15 minutes of an in vitro dissolution test; and a method of preparing the pharmaceutical composition. According to this, in case that the pharmaceutical composition is developed as the multi-unit spheroidal tablet, the dissolution may be accelerated in a condition of a slow stirring rate than that of a conventional pellet formulation or single tablet. Also, proton pump inhibitors (PPI)-based drugs including esomeprazole may be dissociated by gastric acid having a low pH, consequently inducing a decrease in bioavailability of the drug, but the pharmaceutical composition according to this may be minimize this.