MATRICES COVALENTES BIODÉGRADABLES POUR L'ADMINISTRATION D'INSULINE PAR VOIE ORALE DESTINÉE AU CÔLON À ACTIVATION PAR LE MICROBIOTE ET LEUR PROCÉDÉ D'OBTENTION

摘要

The present invention describes a covalent biomaterial formed with gelling feruloylated arabinoxylans that are biogradable and which can be used for the oral administration of insulin directed to the colon. The present invention also relates a method to producing enzymatically covalently crosslinked particles. The aforementioned pharmaceutical composition is suitable for use in the biomedical or pharmaceutical industry as a non-invasive treatment for the oral administration of insulin or insulin analogs form parents with Type I Diabetes.