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MÉTHODES DE TRAITEMENT D'UNE MALADIE LIÉE À UN TROUBLE IMMUNITAIRE PAR RÉDUCTION DE L'AUTORÉACTIVITÉ DANS UN COMPARTIMENT DE LYMPHOCYTES T
MÉTHODES DE TRAITEMENT D'UNE MALADIE LIÉE À UN TROUBLE IMMUNITAIRE PAR RÉDUCTION DE L'AUTORÉACTIVITÉ DANS UN COMPARTIMENT DE LYMPHOCYTES T
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摘要
The described invention provides a pharmaceutical composition comprising a therapeutic amount of an educated mononuclear cell product, a process for preparing the educated mononuclear cell product, and a method for treating a disease characterized by lymphocyte autoreactivity. Mononuclear cells from a diseased subject are co-cultured with a viable population of adherent umbilical cord blood stem cells at at least 80% confluence to form an educated mononuclear cell product. A therapeutic amount of the educated mononuclear cell product is returned by infusion intravascularly to the subject. The therapeutic amount is effective to modulate autoreactivity in a T cell compartment of the subject and to reduce symptoms of the disease characterized by lymphocyte autoreactivity.
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