TRAITEMENT DU CANCER DU SEIN TRIPLE NÉGATIF OU DU CANCER COLORECTAL COMPORTANT DES MÉTASTASES HÉPATIQUES PAR UN ANTICORPS ANTI-PD-L1 ET UN VIRUS ONCOLYTIQUE

摘要

Provided herein are methods of treating a subject with triple negative breast cancer or colorectal cancer. In exemplary embodiments, the method comprises administering to the subject a combination of an oncolytic virus, such as talimogene laherparepvec, and an anti-PD-Ll antibody, such as atezolizumab. In exemplary aspects, the oncolytic virus is administered to the subject at an initial dose followed by a second dose, wherein the initial dose is lower than the second dose. In exemplary aspects, the oncolytic virus is intrahepatically administered to the subject.