BIOCAPTEUR À ONDES ACOUSTIQUES DE SURFACE UTILISANT UN FRONTAL ANALOGIQUE ET DES BANQUES CODÉES D'ADN POUR AMÉLIORER LA LIMITE DE DÉTECTION (LOD) AVEC UN APPAREIL EXEMPLAIRE DE CELUI-CI

摘要

A surface acoustic wave (SAW) performs a rapid, label-free detection of biological species. Biosensing and detection of multiple analytes multiplexed by an array of sensing lanes is configured to enable bio-amplification using engineered DNA encoded libraries as the probe through a phage display procedure to enhance specificity, capture statistics for the detection, screening and analyzing of the analyte in vitro. A biochemical formulation minimizes the limit of detection (LOD) at a threshold magnitude on the order of a femtomolar concentration. Additional enhancement of the apparatus is achieved by use of an analog front end to amplify biochemical events.