DERIVES DE 2-AMINO-2-(1-DODECYL-1H-1,2,3-TRIAZOL-4-YL)PROPANE-1,3-DIOL UTILES DANS LE TRAITEMENT DE MALADIES NEURODGENERATIVES OU DE LA DEPRESSIONS

摘要

The present invention relates to a pharmaceutical composition for use in preventing or treating a neurodegenerative disease or depression comprising derivatives of 2-amino-2-(1-dodecyl-1H-1,2,3-triazol-4-yl)propane-1,3-diol as an active ingredient. In particular, the present invention relates to a pharmaceutical composition for preventing or treating a neurodegenerative disease or depression comprising as an active ingredient the above mentioned compounds which possess an effect of inhibiting ASM activity. In comparison with conventional ASM inhibitor agents, the novel ASM inhibitory compounds of the Chemical Formula 1 according to the present invention are excellent in therapeutic effects such as inhibiting ASM activity, reducing A² plaques in the brain environment of Alzheimer's disease, recovering the damages by autophagy, and ameliorating nerve inflammation. Hence, the compounds of the present invention possess the excellent industrial applicability since they can be used in the development of agents for preventing or treating a neurodegenerative disease including Alzheimer's disease. Further, considering the previous reports that the inhibition of ASM activity is effective in improving depression, the ASM inhibitory compounds of the Chemical Formula 1 according to the present invention can be used effectively as an agent for preventing or treating a neurological disorder including depression.