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系统性红斑狼疮疾病标志性肠道微生物组合及其应用

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摘要

本发明公开了系统性红斑狼疮疾病标志性肠道微生物组合及其应用，具体的本发明通过分别对来自系统性红斑狼疮个体和健康个体的肠微生物样品进行16s rRNA测序，确定SLE患者中存在的水平差异的罗姆布茨菌(Romboutsia)、粪杆菌(Coprobacter)、和己酸菌(Caproiciproducens)，并明确了这些水平差异与系统性红斑狼疮的关系。这些具有水平差异的肠道微生物能够用于预防、诊断/治疗系统性红斑狼疮疾病的组合物或试剂盒。

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公开/公告号CN113832080B

专利类型发明专利
公开/公告日2023.10.20

原文格式PDF
申请/专利权人中山大学附属第三医院（中山大学肝脏病医院）;
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申请/专利号CN202111303502.8
发明设计人林智明;
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申请日2021.11.05
分类号C12N1/20(2006.01);C12Q1/689(2018.01);G01N33/569(2006.01);C12Q1/02(2006.01);A61K45/00(2006.01);A61P37/02(2006.01);C12R1/01(2006.01);
代理机构上海上谷知识产权代理有限公司 31342;
代理人蔡继清
地址 510630 广东省广州市天河区天河路600号
入库时间 2024-02-23 22:40:08

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1. 系统性红斑狼疮疾病标志性肠道微生物组合及其应用 [P] . 中国专利： CN113832080A . 2021-12-24
2. 肠道微生物组合及其作为系统性红斑狼疮标志物的应用 [P] . 中国专利： CN113832079A . 2021-12-24
3. Methods of reducing the possibility of mortality in an animal, virulent expression in an intestinal pathogen, and adhesin / lectin pa-i expression in a bacterial cell, inhibiting adhesin / lectin pa-i expression in an intestinal pathogen, intestine-induced activation of adhesin / lectin pa-i, c4-hsl-induced morphological change of an intestinal pathogen, and bacterial cell adhesion in a mammalian intestine, improvement of intestinal pathogenesis, disease prevention or abnormal condition, skin and respiratory infection, sexually transmitted disease, digestive tract disorder, loss of lactating capacity in an animal, and development of a microbe-mediated epithelial disorder in a nursing-age animal, irrigation of at least a portion of the urinary tract, and for monitoring the administration of poly (ethylene glycol) (peg) to an animal, composition pharmaceuticals, kits for the prevention or therapeutic treatment of bowel-derived sepsis, and for monitoring the administration of poly (ethyle [P] . BR0215954A . 2005-09-13

机译：减少动物死亡，肠道病原体中强毒表达以及细菌细胞中粘附素/凝集素pa-i表达，抑制肠道病原体中粘附素/凝集素pa-i表达，肠道诱导的粘附素活化的方法/凝集素pa-i，c4-hsl诱导的肠道病原体形态变化和哺乳动物肠道细菌细胞粘附，改善肠道发病机制，预防疾病或异常状况，皮肤和呼吸道感染，性传播疾病，消化道疾病，动物泌乳能力的丧失以及哺乳期动物中微生物介导的上皮疾病的发展，至少一部分尿路的冲洗以及用于监测聚乙二醇（peg）的给药动物，组合物药物，用于预防或治疗肠源性败血症并监测多乙
4. spirocyclic heterocyclic compound, pharmaceutical composition, method to bind opioid receptors, methods to prevent or treat pain, gastrointestinal dysfunction, a urogenital tract disorder, an immunomodulatory disorder, an inflammatory disorder, a respiratory function disorder, anxiety, mood disorder, a stress-related disorder, sympathetic nervous system disorder, cough, and a motor disorder, method for treating traumatic injury to the central nervous system, methods for preventing or treating stroke, cardiac arrhythmia, glaucoma, and sexual dysfunction, methods for treating a condition selected from the group consisting of shock, cerebral edema, cerebral ischemia, cerebral deficit after cardiac surgery (bypass) and graft, systemic lupus erythematosus, hodgkin's disease, sjogren's disease, epilepsy, and rejection in organ transplants and skin grafts, and to treat substance dependence, method to improve organ and cell survival, and cardioprotection after myocardial infarction, methods to [P] . BRPI0415165A . 2007-01-09

机译：螺环杂环化合物，药物组合物，阿片受体的结合方法，预防或治疗疼痛，胃肠道功能障碍，泌尿生殖道疾病，免疫调节疾病，炎性疾病，呼吸功能疾病，焦虑症，情绪障碍，与压力有关的方法疾病，交感神经系统疾病，咳嗽和运动障碍，治疗中枢神经系统创伤的方法，预防或治疗中风，心律不齐，青光眼和性功能障碍的方法，治疗选自以下组的疾病的方法包括休克，脑水肿，脑缺血，心脏手术（旁路）和移植后脑缺损，系统性红斑狼疮，霍奇金病，干燥综合征，癫痫和器官移植和皮肤移植排斥反应，以及治疗药物依赖的方法改善器官和细胞存活率以及心肌梗死后的心脏保护作用，
5. Microorganism for drug delivery for the treatment of gastrointestinal diseases expressing and secreting P8 protein and pharmaceutical composition containing the same for prevention or treatment of gastrointestinal diseases [P] . 日本专利： JP2020505910A . 2020-02-27

机译：用于表达和分泌P8蛋白的治疗胃肠道疾病的微生物用药物以及包含该微生物的药物组合物，用于预防或治疗胃肠道疾病