首页> 中国专利> 重组人Neuritin蛋白在制备治疗感音神经性耳聋及相关疾病药物中的应用

重组人Neuritin蛋白在制备治疗感音神经性耳聋及相关疾病药物中的应用

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摘要

本发明公开了重组人Neuritin蛋白在制备治疗感音神经性耳聋及相关疾病药物中的应用。本发明的重组人Neuritin蛋白，其独特的作用将达到甚至超过给予单独的Notch阻断剂或单独使用神经营养因子对损伤毛细胞的再生或营养作用，从而起到治疗感音神经性耳聋及相关疾病的用途。然，实施本申请的任一产品必不一定需要同时达到以上所述的所有技术效果。

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公开/公告号CN109078169B

专利类型发明专利
公开/公告日2022-02-11

原文格式PDF
申请/专利权人杭州师范大学;
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申请/专利号CN201810863738.9
发明设计人杨磊;黄瑾;汪海燕;董玉梅;孙筱品;桂飞;宋晓明;朱井玲;杨怡;洪玉;谌容;
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申请日2018-08-01
分类号A61K38/17(20060101);A61P27/16(20060101);A61P25/00(20060101);
代理机构11315 北京国昊天诚知识产权代理有限公司;
代理人南霆
地址 311121 浙江省杭州市余杭区仓前街道余杭塘路2318号
入库时间 2022-08-23 13:06:28

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1. 重组人Neuritin蛋白在制备治疗感音神经性耳聋及相关疾病药物中的应用 [P] . 中国专利： CN109078169B . 2022.02.11
2. 重组人成纤维细胞生长因子21融合蛋白及其在制备治疗代谢疾病药物中的应用 [P] . 中国专利： CN106397607A . 2017-02-15
3. Protein isolated and htrt preparation, htrt protein fragment, human telomerase, isolated polynucleotide, expression vector, cell, non-human organism, isolated or recombinant antibody, processes for determining whether a compound or treatment is a modulator of an activity or expression of htrt, if a test compound is a modulator of a telomerase reverse transcriptase activity, to identify a compound that modulates htrt activity, to prepare recombinant telomerase, to detect a htrt people product in a sample and the presence of at least one telomerase positive human cell in a biological sample, to diagnose a telomerase-related condition in a patient and cancer to provide a prognosis for a cancer patient, to monitor the ability of an anti-cancer treatment, to reduce the ability proliferation of cancer cells in a patient, to increase the proliferative capacity of a vertebrate cell, to treat a condition associated with a high level of telomerase activity within a cell, to isolate a selected nu [P] . BR9712254A . 2000-01-18

机译：分离的蛋白和htrt制剂，htrt蛋白片段，人类端粒酶，分离的多核苷酸，表达载体，细胞，非人类有机体，分离的或重组抗体，确定化合物或治疗是否是htrt活性或表达调节剂的过程，如果受试化合物是端粒酶逆转录酶活性的调节剂，则鉴定可调节htrt活性的化合物，制备重组端粒酶，检测样品中的htrt人产物以及是否存在至少一个端粒酶阳性人类细胞生物学样品，以诊断患者和癌症中的端粒酶相关病症，为癌症患者提供预后，以监测抗癌治疗的能力，减少患者癌细胞的增殖能力，从而增加癌症患者的预后。脊椎动物细胞的增殖能力，用于治疗与细胞内端粒酶活性高水平有关的疾病，分离选定的核酸
4. isolated protein, isolated nucleic acid molecule, recombinant vector, host cell, method of producing a hybrid actriib protein, pharmaceutical composition, methods of treating myostatin or activin-related disorders, muscle wasting disease, disease cardiovascular disease, metabolic disorders, cancer cells, kidney disease, inflammatory / autoimmune disease, fibrosis disease, anemia, pain, aging condition, bone disorders, muscle wasting or metabolic disorder or fibrotic or inflammatory or activin-related in individuals, and a method of inducing stem cell growth for tissue repair or organ regeneration in an individual [P] . BR112017022658A2 . 2018-07-17

机译：分离的蛋白质，分离的核酸分子，重组载体，宿主细胞，生产杂化阿特丽单抗的方法，药物组合物，治疗肌生长抑制素或激活素相关疾病的方法，肌肉萎缩性疾病，心血管疾病，代谢性疾病，癌细胞，肾脏疾病，炎性/自身免疫性疾病，纤维化病，贫血，疼痛，衰老，骨骼疾病，肌肉萎缩或代谢异常或与纤维化或炎性或激活素相关的个体，以及诱导干细胞生长以进行组织修复或器官再生的方法在个人中
5. Hmw protein of the isolated chlamydia species, isolated nucleic acid molecule, recombinant expression vector, transformed host cell, isolated recombinant protein or fragment or analog thereof, immunogenic composition, antigenic composition, processes to produce an immune response in an animal, anti- serum, antibodies, diagnostic reagent, to detect anti-chlamydia antibodies in a test sample, to detect the presence of chlamydia in a test sample, to prevent, treat or ameliorate a chlamydia-related disorder in a host in need of this treatment , and to determine the presence of nucleic acid encoding an hmw protein or a fragment or analog thereof in a sample, diagnostic kits to detect antibodies to chlamydia, and to determine the presence of nucleic acid encoding an hmw protein or fragment or analog thereof in a sample, vaccine composition, and pharmaceutical composition The [P] . BR9813841A . 2000-10-03

机译：分离的衣原体物种的Hmw蛋白，分离的核酸分子，重组表达载体，转化的宿主细胞，分离的重组蛋白或其片段或类似物，免疫原性组合物，抗原性组合物，在动物中产生免疫应答的过程，抗血清，抗体，诊断试剂，用于检测测试样品中的衣原体抗体，检测测试样品中的衣原体，预防，治疗或缓解需要此治疗的宿主中的衣原体相关疾病，并确定样品中是否存在编码hmw蛋白或其片段或类似物的核酸，诊断试剂盒以检测针对衣原体的抗体以及确定样品，疫苗组合物中是否存在编码hmw蛋白或其片段或类似物的核酸和药物成分