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用于药物代谢检测的羧酸酯酶抑制剂制剂

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摘要

本申请提供了一种用于药物代谢检测的羧酸酯酶抑制剂制剂，所述羧酸酯酶抑制剂制剂由苯甲基磺酰氟和氯化钙组成，该羧酸酯酶抑制剂制剂抑制率高，且不受抗凝血剂肝素的影响，可以与肝素配合制成血液保存剂。

著录项

公开/公告号CN110208411B

专利类型发明专利
公开/公告日2021-12-24

原文格式PDF
申请/专利权人浙江龙传生物医药科技有限公司;
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申请/专利号CN201910495157.9
发明设计人范敏华;徐怀友;蔡卫东;章莹;
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申请日2019-06-10
分类号G01N30/02(20060101);G01N30/06(20060101);G01N33/86(20060101);
代理机构33298 杭州恒翌专利代理事务所(特殊普通合伙);
代理人柯奇君
地址 310018 浙江省杭州市钱塘新区下沙街道福成路291号和达药谷中心1-1203室
入库时间 2022-08-23 12:59:44

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5. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

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