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一种具有抑制黑色素生成和抗紫外线损伤作用的美白还原多肽及其应用

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摘要

本发明涉及一种具有抑制黑色素生成和抗紫外线损伤作用的美白还原多肽，所述美白还原多肽是具有SEQ ID NO:1‑SEQ ID NO:5中任一项所述的氨基酸序列的多肽。本发明还提供一种上述美白还原多肽的应用，其中，该美白还原多肽应用于化妆品或口服液领域。本发明提供的美白还原多肽，同时具备酪氨酸酶抑制能力和抗氧化能力，而且具有稳定的生物相容性。

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公开/公告号CN109180785B

专利类型发明专利
公开/公告日2021-08-20

原文格式PDF
申请/专利权人中国科学院上海应用物理研究所;
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申请/专利号CN201811325592.9
发明设计人沈志伟;张益;
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申请日2018-11-08
分类号C07K7/06(20060101);C07K5/113(20060101);A61K8/64(20060101);A61Q19/02(20060101);A61Q19/08(20060101);A61Q19/00(20060101);A61Q17/04(20060101);
代理机构31002 上海智信专利代理有限公司;
代理人邓琪
地址 201800 上海市嘉定区嘉罗公路2019号
入库时间 2022-08-23 12:20:43

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1. 一种具有抑制黑色素生成和抗紫外线损伤作用的美白还原多肽及其应用 [P] . 中国专利： CN109180785B . 2021.08.20
2. 一种具有抑制黑色素生成和抗紫外线损伤作用的美白还原多肽及其应用 [P] . 中国专利： CN109180785A . 2019-01-11
3. Marker gene pool, method for assessing the reparative and / or therapeutic protective effects of ultraviolet radiation of a compound or material, compound or material having ultraviolet protective, repairing or therapeutic effects, methods for improving and / or treating, for reversing and / or repair photo-damaged or photo-aged skin, and to assess whether a substance can repair or reverse the effects of photo-damage or photoaging related to UV radiation exposure, substance or material having photo-repairing or reversing effects or photoaging, composition or formulation, photoprotective or photoprotective or anti-photoaging formulation, methods for assessing skin damage or an ultraviolet-induced skin replacement following exposure to uv radiation, to prevent photoaged or photoavariated skin, to identify or select individuals who are susceptible useful or highly sensitive to skin photoaging or photoaging following exposure to UV radiation, and kit for assessing the photoaging or photoag [P] . BR0209510A . 2006-02-07

机译：标记基因库，评估化合物或材料的紫外线的修复和/或治疗保护作用的方法，具有紫外线保护，修复或治疗作用的化合物或材料，改善和/或治疗，逆转和/或修复的方法光损伤或光老化的皮肤，并评估一种物质是否可以修复或逆转与紫外线辐射，光修复或逆转作用或光老化，组成或配方有关的物质或材料的光损伤或光老化的影响，光保护或光保护或抗光老化制剂，评估暴露于uv辐射后皮肤损伤或紫外线引起的皮肤置换，预防光老化或光变皮肤，鉴定或选择对皮肤光老化有用或高度敏感的个体的方法暴露于紫外线辐射后发生光老化，以及用于评估光老化或光敏性的试剂盒
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机译：分离的多核苷酸，表达盒，宿主细胞，分离的多肽，已被改变以表达耐碱突变体多肽的非人类转基因动物，与耐碱突变体多肽特异性结合的抗体，突变检测试剂盒生物样品，以及用于评估生物样品中是否存在对烷基抑制剂的抗性突变以诊断对至少一种碱性抑制剂有抗药性或可能发展出抗药性的癌症的方法。小分子激酶，用于评估生物学样品中是否具有抑制碱性磷酸酶抑制剂的突变，以诊断对患者具有抗药性或可能对pf-02341066产生抗药性的癌症，从而特异性降低抗癌突变体的表达以治疗癌症与激活抗至少一种小分子烷基激酶抑制剂的异常环路能力有关，该抑制剂治疗对pf-02341066有抵抗力的异常癌症
5. D- Melanogenesis Inhibitor Comprising D-Pantothenyl Alcohol and Skin-Whitening Cosmetic Containing Same Melanogenesis Inhibitor [P] . 韩国专利： KR102128312B1 . 2020-06-30

机译：包含D-泛烯醇和含有相同黑色素生成抑制剂的美白化妆品的D-黑色素生成抑制剂