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一种治疗胃肠道疾病的生物粘附性纳米粒及其制备方法

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摘要

本发明属于药物载体材料技术领域，具体涉及一种治疗胃肠道疾病的生物粘附性纳米粒及其制备方法，本发明将用于治疗胃肠道疾病的药物与可生物降解的PLA、HPG制备成非生物粘性的可降解纳米粒子药物/NNPs，药物/NNPs再经高碘酸钠氧化还原后成为具有生物粘性的可降解纳米粒子药物/BNPs，由于所制得的生物粘附性纳米粒BNPs可以与胃肠道系统的蛋白连接，从而能够黏附在组织上，缓慢释放药物，实现食道内药物的靶向性释放，进而发挥更好的治疗效果，并降低副作用。

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公开/公告号CN113876716A

专利类型发明专利
公开/公告日2022-01-04

原文格式PDF
申请/专利权人中山大学·深圳;中山大学;
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申请/专利号CN202111198091.0
发明设计人麦扬;欧阳亚琪;刘洋;邓扬;
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申请日2021-10-14
分类号A61K9/16(20060101);A61K47/34(20170101);A61K45/06(20060101);A61K31/4422(20060101);A61P1/00(20060101);C08G81/00(20060101);C08G65/28(20060101);
代理机构44367 深圳市创富知识产权代理有限公司;
代理人叶灿才
地址 518107 广东省深圳市光明新区光明街道华夏路和润家园3栋501
入库时间 2023-06-19 13:33:57

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法律状态
2023-03-10

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1. 一种治疗胃肠道疾病的生物粘附性纳米粒及其制备方法 [P] . 中国专利： CN113876716A . 2022-01-04
2. 一种核壳结构生物粘附性聚合物纳米粒子及其制备方法和应用 [P] . 中国专利： CN104610497A . 2015-05-13
3. A therapeutically active, substituted benzimidazole derivative and physiologically acceptable salts and optical enantiomers thereof and a process for preparing them, a pharmaceutical preparation which comprises the benzimidazole derivative, the use of the derivative for producing a medicament for inhibiting gastric acid secretion in mammals and for treating inflammatory gastrointestinal disorders in mammals, and an intermediate compound for preparing the derivative [P] . DK170801B1 . 1996-01-22

机译：具有治疗活性的取代的苯并咪唑衍生物及其生理上可接受的盐和旋光对映体及其制备方法，包含苯并咪唑衍生物的药物制剂，该衍生物在制备抑制哺乳动物胃酸分泌的药物中的用途和用于治疗哺乳动物的炎症性胃肠道疾病，以及用于制备衍生物的中间体化合物
4. compound of formula i; pharmaceutical composition; method of treating disorders that are related to or affected by inhibition of norepinephrine reuptake, the 5-ht6 receptor or the 5-ht2a receptor; a method of treating a learning disorder, a cognitive disorder, a memory disorder, a personality disorder, a behavioral disorder, a movement disorder, a neurodegenerative disorder, drug withdrawal disorder, sleep, an eating disorder, acute drug toxicity, a cardiovascular disorder, a sexual dysfunction, a gastrointestinal disorder, a genitourinary disorder, a pain disorder, a nervous disorder or a symptom disorder vasomotor; method of treating alzheimer's disease, attention deficit disorder, schizophrenia, parkinson's disease, tardive dyskinesia, ataxia, bradykinesia, paroxysmal dyskinesias, restless leg syndrome, tremor, essential tremor epilepsy, stroke or head trauma; method of treating coronary artery disease, myocardial infarction, transient ischemic attack, angina, atrial fibrillation, p [P] . BRPI0706523A2 . 2011-01-04

机译：式I化合物;药物组合物;治疗与去甲肾上腺素再摄取，5-ht6受体或5-ht2a受体相关或受其抑制的疾病的方法;一种治疗学习障碍，认知障碍，记忆障碍，人格障碍，行为障碍，运动障碍，神经退行性疾病，戒断药物，睡眠，进食障碍，急性药物毒性，心血管疾病的方法，性功能障碍，胃肠道疾病，泌尿生殖系统疾病，疼痛疾病，神经疾病或症状-血管舒缩;治疗阿尔茨海默氏病，注意力缺陷障碍，精神分裂症，帕金森氏病，迟发性运动障碍，共济失调，运动迟缓，阵发性运动障碍，不安腿综合征，震颤，原发性震颤癫痫，中风或头部外伤的方法;治疗冠状动脉疾病，心肌梗塞，短暂性脑缺血发作，心绞痛，心房颤动，p的方法
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机译：减少动物死亡，肠道病原体中强毒表达以及细菌细胞中粘附素/凝集素pa-i表达，抑制肠道病原体中粘附素/凝集素pa-i表达，肠道诱导的粘附素活化的方法/凝集素pa-i，c4-hsl诱导的肠道病原体形态变化和哺乳动物肠道细菌细胞粘附，改善肠道发病机制，预防疾病或异常状况，皮肤和呼吸道感染，性传播疾病，消化道疾病，动物泌乳能力的丧失以及哺乳期动物中微生物介导的上皮疾病的发展，至少一部分尿路的冲洗以及用于监测聚乙二醇（peg）的给药动物，组合物药物，用于预防或治疗肠源性败血症并监测多乙