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一种乳腺癌相关基因PIK3CA-Q928H突变体及其特异性引物

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摘要

本发明公开了一种乳腺癌相关基因PIK3CA‑Q928H突变体及其特异性引物，属于分子生物学技术领域，公开了一种乳腺癌PIK3CA基因g.179230121A>C位点突变及其应用。该PIK3CA基因突变与PIK3CA正常基因序列相比具有g.179230121A>C位点突变。本发明提供了乳腺癌相关基因新的突变位点，可用于早期乳腺癌筛查。

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公开/公告号CN112941187A

专利类型发明专利
公开/公告日2021-06-11

原文格式PDF
申请/专利权人无锡市第五人民医院;
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申请/专利号CN202110361334.1
发明设计人顾娟;王玥苹;周道平;吴怀国;唐海林;郑国沛;
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申请日2021-04-02
分类号C12Q1/6886(20180101);C12N15/11(20060101);C12N15/54(20060101);
代理机构32316 无锡松禾知识产权代理事务所(普通合伙);
代理人朱亮淞
地址 214000 江苏省无锡市梁溪区广瑞路1215号
入库时间 2023-06-19 11:22:42

法律信息

法律状态公告日

法律状态信息

法律状态
2023-08-11

发明专利申请公布后的视为撤回 IPC(主分类):C12Q 1/6886 专利申请号:2021103613341 申请公布日:20210611

发明专利申请公布后的视为撤回

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1. 一种乳腺癌相关基因PIK3CA-Q928H突变体及其特异性引物 [P] . 中国专利： CN112941187A . 2021-06-11
2. 一种乳腺癌易感基因BRCA2-K2305N突变体及其特异性引物 [P] . 中国专利： CN112941186A . 2021-06-11
3. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

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4. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

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5. Processes for detecting a mutation in the nucleic acid to detect fungal and fungal resistance to an analogue of estobilurina,Fungal DNA sequence encoding all or part of a proteu00ecna of cytochrome b, cytochrome b proteu00ecna fungal.The allele specific oligonucleotu00ecdeo capable of connecting to a sequence of fungal nucleic acid, initiator of diagnosis or diagnostic oligonucleotu00ecdeo capable of connecting to a template.One or more diagnostic primers, probe the allele specific oligonucleotu00ecdeo, diagnostic kit to detect fungal pathogen resistance, process plant, a fungicide.To detect and quantify the frequency of mutation, to select a fungicide active and their nu00ecveis optimal implementation, and to control the fungal infection of a collection, and,A computer legu00ecvel [P] . BR0010163A . 2002-01-15

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