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一种作用舌咽迷走神经调控CCK肽治疗抑郁症的药物及其制备方法和使用方法

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摘要

本发明公开了一种作用舌咽迷走神经调控CCK肽治疗抑郁症的药物，含远志糖苷化合物或其可药用盐、酯或溶剂化物。制备成舌咽喷雾剂或/和口腔含剂（片剂、液剂）给药。药物直接与口腔舌苔、咽、喉的迷走神经接触吸收，通过CCK神经肽调节迷走神经下丘脑‑垂体‑肾上腺轴(HPA轴)功能紊乱，达到安全、快速、高效、低成本治疗抑郁症的显著效果。

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公开/公告号CN112472707A

专利类型发明专利
公开/公告日2021-03-12

原文格式PDF
申请/专利权人杨浚;
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申请/专利号CN202011585754.X
发明设计人杨浚;
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申请日2020-12-29
分类号A61K31/7024(20060101);A61P25/24(20060101);A61P25/28(20060101);C07H1/00(20060101);C07H13/04(20060101);
代理机构43103 岳阳市大正专利事务所(普通合伙);
代理人皮维华
地址 414000 湖南省岳阳市岳阳楼区岳阳市科技局4栋1304
入库时间 2023-06-19 10:14:56

法律信息

法律状态公告日

法律状态信息

法律状态
2022-11-22

发明专利申请公布后的视为撤回 IPC(主分类):A61K31/7024 专利申请号:202011585754X 申请公布日:20210312

发明专利申请公布后的视为撤回

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1. 一种作用舌咽迷走神经调控CCK肽治疗抑郁症的药物及其制备方法和使用方法 [P] . 中国专利： CN112472707A . 2021-03-12
2. 一种作用胃脾肠脑轴迷走神经调控CCK肽治疗抑郁症的药物及其制备方法和使用方法 [P] . 中国专利： CN112494582A . 2021-03-16
3. METHOD OF FORECASTING DEPRESSION TREATMENT EFFECTIVENESS BY APPLYING ELECTROACUPUNCTURE AND ACUPUNCTURE EXAMINATION OF THE AURICULAR ZONES OF THE NERVOUS VAGUS, FACIALIS AND GLOSSOPHARYNGEUS [P] . SU1734686A1 . 1992-05-23

机译：通过电针和电针检查神经迷走神经，面部和舌咽的带状区域预测抑郁症治疗效果的方法
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机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法
5. compound, pharmaceutical composition, method of selective activation/stimulation of nicotinic receptors from to-7 in a patient in which such activation/stimulation has a therapeutic effect, method of treating a patient suffering from a psychotic disease, a neurodegenerative disease involving a dysfunction of the cholinergic system, and/or a condition of impaired memory and/or cognition, method of treatment of a patient suffering from dementia and/or another condition with memory loss, method of treatment of a patient suffering from memory impairment due to mild cognitive impairment due to aging, alzheimer's malady,schizophrenia, parkinson malady, huntington malady, pick malady, creutzfeldt-jakob malady, depression, aging, head trauma, stroke, snc hypoxia, cerebral senility, multiinfarction dementia, HIV and/or cardiovascular disease, method of treatment and/or prevention of dementia in a patient with alzheimer's disease, method of treating a patient to cut off the alcohol vein or treat [P] . BRPI0517494A . 2008-10-14

机译：化合物，药物组合物，在其中这种激活/刺激具有治疗作用的患者中选择性激活/刺激烟碱受体从to-7的方法，治疗患有精神病，涉及神经功能障碍的神经退行性疾病的患者的方法胆碱能系统和/或记忆力和/或认知障碍的状况，患有痴呆症的患者的治疗方法和/或患有记忆力丧失的另一种状况，由于轻度认知障碍而遭受记忆力障碍的患者的治疗方法由于衰老，阿尔茨海默氏病，精神分裂症，帕金森氏病，亨廷顿氏病，匹克病，creutzfeldt-jakob病，抑郁症，衰老，头部外伤，中风，snc缺氧，脑衰老，多发性梗塞性痴呆，HIV和/或心血管疾病，治疗方法治疗和/或预防老年痴呆症患者的痴呆症，治疗患者的方法以切断酒精静脉或治疗