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Effectiveness and cost-effectiveness of an awareness campaign for colorectal cancer: a mathematical modeling study

机译:结直肠癌意识活动的有效性和成本效益:数学模型研究

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BackgroundududA campaign to increase the awareness of the signs and symptoms of colorectal cancer (CRC) and encourage self-presentation to a GP was piloted in two regions of England in 2011. Short-term data from the pilot evaluation on campaign cost and changes in GP attendances/referrals, CRC incidence, and CRC screening uptake were available. The objective was to estimate the effectiveness and cost-effectiveness of a CRC awareness campaign by using a mathematical model which extrapolates short-term outcomes to predict long-term impacts on cancer mortality, quality-adjusted life-years (QALYs), and costs.ududMethodsududA mathematical model representing England (aged 30+) for a lifetime horizon was developed. Long-term changes to cancer incidence, cancer stage distribution, cancer mortality, and QALYs were estimated. Costs were estimated incorporating costs associated with delivering the campaign, additional GP attendances, and changes in CRC treatment.ududResultsududData from the pilot campaign suggested that the awareness campaign caused a 1-month 10 % increase in presentation rates. Based on this, the model predicted the campaign to cost £5.5 million, prevent 66 CRC deaths and gain 404 QALYs. The incremental cost-effectiveness ratio compared to “no campaign” was £13,496 per QALY. Results were sensitive to the magnitude and duration of the increase in presentation rates and to disease stage.ududConclusionsududThe effectiveness and cost-effectiveness of a cancer awareness campaign can be estimated based on short-term data. Such predictions will aid policy makers in prioritizing between cancer control strategies. Future cost-effectiveness studies would benefit from campaign evaluations reporting as follows: data completeness, duration of impact, impact on emergency presentations, and comparison with non-intervention regions.
机译:背景 ud ud 2011年在英格兰的两个地区开展了一项旨在提高对结直肠癌(CRC)的体征和症状的认识并鼓励向GP自我介绍的运动。该运动的先导评估短期数据来自运动成本以及GP出勤/转诊,CRC发病率和CRC筛查摄取率的变化。目的是通过使用数学模型来估算CRC意识运动的有效性和成本效益,该数学模型可以推断短期结果以预测对癌症死亡率,质量调整生命年(QALY)和成本的长期影响。 ud udMethods ud ud建立了代表英格兰(30岁以上)的终身视野的数学模型。估计了癌症发生率,癌症分期,癌症死亡率和QALYs的长期变化。估算成本,其中包括与开展活动有关的成本,额外的全科医生出席率以及CRC治疗的变化。 ud udResults ud ud来自试点活动的数据表明,宣传活动使展示率提高了1个月10%。基于此,模型预测该运动将花费550万英镑,防止66名CRC死亡,并获得404个QALY。与“无竞选”相比,每QALY的成本效益比增加了13,496英镑。结果对出现率增加的幅度和持续时间以及疾病阶段很敏感。结论ud癌症癌症认识运动的有效性和成本效益可以基于短期数据进行估算。这样的预测将有助于决策者确定癌症控制策略之间的优先级。未来的成本效益研究将受益于运动评估报告,报告如下:数据完整性,影响持续时间,对紧急情况的影响以及与非干预区域的比较。

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    Whyte S.; Harnan S.;

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