Background: Stasis of the blood has been postulated as a major cause of venous thrombosis. However, little is known about the effect of stimulating the blood flow in order to prevent venous thrombosis through, for example, sports activities.ududObjectives: In a large population-based case-control study (MEGA study), we studied whether participating in sports activities on a regular basis was associated with venous thrombosis risk.ududPatients/methods: Consecutive patients with a first venous thrombosis of the leg or a pulmonary embolism, and control subjects, consisting of partners of the patients and randomly selected control subjects from the general population, were asked to participate. Sports activities and other risk factors for venous thrombosis were reported in a standardized mailed questionnaire. Participants with malignancy were excluded.ududResults: Out of 3608 patients, 1136 (31.5%), and of our 4252 control subjects 1686 (39.7%), participated in sports activities. Participating in sports activities reduced the risk of venous thrombosis compared with not participating in sports activities [odds ratio (OR) 0.64; 95% CI 0.58–0.71]. Risk reductions were similar after adjustment for sex, age and body mass index (ORadj 0.71; 95% CI 0.64–0.78) and when the analysis was restricted to healthy individuals (ORadj 0.67; 95% CI 0.58–0.78). No differences in risk were found for various frequencies, intensities and types of sportud
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机译:背景:血液淤积被认为是静脉血栓形成的主要原因。但是,对于通过运动等预防静脉血栓形成的刺激血流的效果知之甚少。 ud ud目标:在一项基于人群的大型病例对照研究(MEGA研究)中,我们研究了是否定期参加体育活动与静脉血栓形成风险相关。 ud ud患者/方法:with连续发生腿部或肺栓塞的首例静脉血栓形成的连续患者,以及由患者伴侣组成并随机选择的对照组来自一般人群的对照受试者,被要求参加。在一份标准化的邮寄问卷中报告了体育活动和其他静脉血栓形成的危险因素。结果:在3608例患者中,有1136例(31.5%)和我们的4252例对照受试者1686例(39.7%)参加了体育活动。与不参加体育活动相比,参加体育活动减少了静脉血栓形成的风险[比值比(OR)为0.64; 95%CI 0.58–0.71]。调整性别,年龄和体重指数后的风险降低相似(ORadj 0.71; 95%CI 0.64-0.78),而分析仅限于健康个体(ORadj 0.67; 95%CI 0.58-0.78)。对于各种频率,强度和运动类型,发现风险没有差异
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