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Determinants of pharmaceutical innovation diffusion: social contagion and prescribing characteristics

机译:药物创新扩散的决定因素:社会蔓延和处方特征

摘要

This article studies the determinants of pharmaceutical innovation diffusion amongudspecialists. To this end, it investigates the influences of six categories of factors—socialudembeddedness, socio-demography, scientific orientation, prescribing patterns, practiceudcharacteristics, and patient panel composition—on the use of new drugs for the treatment ofudtype 2 diabetes mellitus in Hungary. Here, in line with international trends, 11 brands wereudintroduced between April 2008 and April 2010, outperforming all other therapeutic classes.udThe Cox proportional hazards model identifies three determinants—social contagion (in theudsocial embeddedness category) and prescribing portfolio and insulin prescribing ratio (in theudprescribing pattern category). First, social contagion has a positive effect amongudgeographically close colleagues—the higher the adoption ratio, the higher the likelihood ofudearly adoption—but no influence among former classmates and scientific collaborators.udSecond, the wider the prescribing portfolio, the earlier the new drug uptake. Third, the lowerudthe insulin prescribing ratio, the earlier the new drug uptake—physicians’ therapeutic convictions and patients’ socioeconomic statuses act as underlying influencers. However, this finding does not extend to opinion-leading physicians such as scientific leaders and hospitaluddepartment and outpatient center managers. This article concludes by arguing that healthcare policy strategists and pharmaceutical companies may rely exclusively on practice location and prescription data to perfect interventions and optimize budgets.
机译:本文研究了专家之间药物创新扩散的决定因素。为此,它研究了六类因素的影响-社会去皮,社会人口统计学,科学取向,处方模式,实践特征和患者组组成-对使用新药物治疗 udtype 2的影响。匈牙利的糖尿病。在这里,根据国际趋势,在2008年4月至2010年4月之间推出了11个品牌,其表现优于所有其他治疗类别。 udCox比例风险模型可识别三个决定因素:社会传染性(在 udsocial嵌入性类别中),处方组合和胰岛素处方比例(在处方类型类别中)。首先,社会传染在预算上亲密的同事中具有积极作用-收养率越高,被近收养的可能性越高–但对以前的同学和科学合作者没有影响。 ud其次,处方组合越广,越早新药吸收。第三,胰岛素处方的比率越低,新药的吸收就越早-医生的治疗信念和患者的社会经济地位是潜在的影响因素。但是,此发现并未扩展到意见领先的医师,例如科学领导者,医院/部门以及门诊中心经理。本文的结论是,医疗保健政策策略师和制药公司可能会完全依赖实践地点和处方数据来完善干预措施并优化预算。

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