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Mobility assessment in people with Alzheimer disease using smartphone sensors

机译:使用智能手机传感器的阿尔茨海默病人们的流动性评估

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摘要

Abstract Background Understanding the functional status of people with Alzheimer Disease (AD), both in a single (ST) and cognitive dual task (DT) activities is essential for identifying signs of early-stage neurodegeneration. This study aims to compare the performance quality of several tasks using sensors embedded in an Android device, among people at different stages of Alzheimer and people without dementia. The secondary aim is to analyze the effect of cognitive task performance on mobility tasks. Methods This is a cross-sectional study including 22 participants in the control group (CG), 18 in the group with mild AD and 22 in the group with moderate AD. They performed two mobility tests, under ST and DT conditions, which were registered using an Android device. Postural control was measured by medial-lateral and anterior-posterior displacements of the COM (MLDisp and APDisp, respectively) and gait, with the vertical and medial-lateral range of the COM (Vrange and MLrange). Further, the sit-to-stand (PStand) and turning and sit power (PTurnSit), the total time required to complete the test and the reaction time were measured. Results There were no differences between the two AD stages either for ST or DT in any of the variables (p > 0.05). Nevertheless, people at both stages showed significantly lower values of PStand and PTurnSit and larger Total time and Reaction time compared to CG (p < 0.05). Further, Vrange is also lower in CDR1G than in CG (p < 0.05). The DT had a significant deleterious effect on MLDisp in all groups (p < 0.05) and on APDisp only in moderate AD for DT. Conclusions Our findings indicate that AD patients present impairments in some key functional abilities, such as gait, turning and sitting, sit to stand, and reaction time, both in mild and moderate AD. Nevertheless, an exclusively cognitive task only influences the postural control in people with AD.
机译:摘要背景理解患有阿尔茨海默病(AD)的人的功能状况,无论是单一(ST)和认知双重任务(DT)活动都对于鉴定早期神经变性的迹象至关重要。本研究旨在使用嵌入在Android设备中的传感器的多个任务的性能质量进行比较,在阿尔茨海默氏症和没有痴呆的人的不同阶段的人们中。二次目的是分析认知任务性能对移动任务的影响。方法这是一个横截面研究,包括对照组(CG)中的22名参与者,其中18名,其中18名,具有温和Ad和22个中的22例,具有中度广告。它们在ST和DT条件下执行了两个移动性测试,使用Android设备注册。通过COM(MLDISP和APDISP)和步态的内侧和前后位移测量姿势对照,具有COM(VRange和MLRANGE)的垂直和内侧横向范围。此外,测量了静止式(Pterstand)和转动和坐标(Pturnsit),完成测试所需的总时间和反应时间。结果在任何变量中的ST或DT的两个广告阶段之间没有差异(P> 0.05)。然而,与CG相比,两个阶段的人们显着降低了PASTOM和PTurnsit的值,总时间和反应时间更大(P <0.05)。此外,VRange在CDR1G中也比CG更低(P <0.05)。 DT对所有群体中的MLDISP有重大有害影响(P <0.05),并且仅在适度的AD中对DT的APDISP进行了显着的有害影响。结论我们的研究结果表明,AD患者在一些关键功能能力中存在损伤,例如步态,转动和坐着,坐在轻度和中度广告中,坐在展台和反应时间。然而,专门的认知任务只会影响广告的人们的姿势控制。

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