Final Report on the Developmental Toxicity of 'd'-Camphor (Cas No. 464-49-3) inNew Zealand White (NZW) (Trade Name) Rabbits. Laboratory Supplement. Sections 1-7A

摘要

In the study, female New Zealand white rabbits were dosed by gavage with eithercamphor (50, 200, or 400 mg/kg body wt/day) or vehicle (corn oil) on gestational days 6 through 19. Necropsy was conducted on gestational day 30 and the following determinations were made: clinical condition; maternal body, liver, gravid uterine weights; pregnancy status and the number of corpora lutea. The number of deaths (resorptions and/or dead fetuses) and the numbers of live fetuses were also recorded. The laboratory supplement describes methods used in the study and a chemical analysis of the study compound. Results are presented in a second document.