Review of Jorgenson/SRI Tumor Incidence Data for Rats and Mice Exposed toChloroform in Drinking Water Implications for Chloroform Risk Assessment

摘要

The purpose of the review was to revisit a mouse and rat bioassay for chloroformin drinking water done under contract for EPA and reported in the literature by Jorgenson et al, in 1985. The review had several objectives including to reconcile apparently different records of tumor counts, to elucidate additional tumor occurences that were reported but not discussed in detail, and to consider anaimal-at-risk counts that would be important for quantitative risk analysis. These topics are viewed as important considerations because EPA's present chloroform cancer risk characterization depends heavily on this bioassay; yet, the detained bioassay reports have never been scrutinized.