Developmental Toxicity Evaluation for Sodium Thioglycolate (CAS No. 367-51-1)Administered Topically to New Zealand White Rabbits on Gestational Days 6 through 29 (Includes Laboratory Supplement)

摘要

The thioglycolic acids, which include the salt sodium thioglycolate, havewidespread occupational and consumer exposure because of their use in cosmetics and hair-care products. As constituents of those types of products, their use is predominantly focused on the female population. Such a high probability for female exposure expands the potential for the thioglycolic acids to interact with the unborn human. The following study was performed to assess the developmental toxicity of sodium thioglycolate when administered topically to the dorsum of pregnant rabbits at doses selected from the range-finding study results. New Zealand White Rabbits were topically exposed to sodium thioglycolate in vehicle (10, 15, 25, and 65 mg/kg/day) or vehicle alone (95% ethanol; distilled water, 1:1) from gestational day (gd) 6 through 29.