Final Study Report: Developmental Toxicity Evaluation for Sodium Thioglycolate(CAS No. 367-51-1) Administered Topically to Sprague-Dawley (CD)(Trade Name) Rats on Gestational Days 6 through 19

摘要

The thioglycolic acids, which include the salt sodium thioglycolate, have awidespread occupational and consumer exposure because of their use in cosmetics and hair-care products. As constituents of those types of products, their use is predominantly focused on the female population. Such a high probability for female exposure expands the potential for the thioglycolic acids to interact with the unborn human. The study was performed to assess the developmental toxicity of sodium thioglycolate, a representative compound of the thioglycolates, when administered topically to the dorsum of pregnant rats at doses selected from the range-finding study results. Pregnant Sprague Dawley derived (CD (trademark)) rats were topically exposed to sodium thoglycolate in vehicle (50, 100, and 200 mg/kg/day) or vehicle alone (95% ethanol:distilled water, 1:1) from gestational day (gd) 6 through 19. Twenty-five timed-mated females were assigned to each group and monitored at regular intervals throughout gestation for clinical signs (including dosing site condition), feed and water intake, and body weight.