Metalloproteins Containing Iron and Tungsten: Biocatalytic Links between Organic and Ionorganic Redox Chemistry

摘要

Important chemical reactions in the metabolic pathways of living organisms involve redox reactions. Frequently transitions metals are used in enzymes to perform redox catalysis. This thesis reports studies on a set of proteins and enzymes containing iron and/or tungsten as redox catalysts or electron carriers: the (4Fe-4S) containing ferredoxin, Fe(Cys)4 containing rubredoxin, the (4Fe-4S) and tungsten containing glyceraldehydes-3-phosphate oxidoreductase, the tungsten containing DMSO reductase, the non-heme iron containing human phenylalanine hydroxylase, and the heme iron containing chlorite dismutase.